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DiscussionSwitching from alendronate to something else
Osteoporosis & Bone Health | Last Active: May 11 8:58am | Replies (14)Comment receiving replies
Replies to "Has anyone heard of or tried NAD+which is suppose to “wake up” osteoblasts? Just reading about..."
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@sharonkay I too have been reading about NAD+, and looking for the science behind the recommendations.
What did I learn?
Mayo Clinic has looked at NAD supplementation, and has cautions about using it:
https://www.nad.com/news/nad-precursor-nrh-inflammation-macrophage-immune-cells
Most of the studies reporting increased osteoblasts so far were performed on mice. Have you seen any independent studies involving humans?
There is a very interesting article about how much NAD+ is enough, and whether it should be taken routinely as a supplement, since we don't yet know the full long-term effects of using it. Here is a chart from the the article Oxford Journal that outlines the gaps in our knowledge:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10692436/figure/F5/
Finally, I think the label on Thryve NAD+ label, on their own website, says it all: "RESEARCH USE ONLY NOT FOR HUMAN CONSUMPTION"
Remember, these supplements are neither regulated nor tested by the FDA.