I’ve had two shots of Leqvio, with a third one scheduled in a couple of weeks. So far, I haven’t had any side effects.
I’ve seen people say that Leqvio doesn’t lower Lp(a), but I think part of the confusion comes from expectations. If someone starts with very high Lp(a), then even a 30% drop might not feel significant to them—yet it’s still a real improvement.
Here are my own results, comparing before Leqvio vs. after Leqvio:
Lp(a): 115.2 → 63 (41% decrease)
LDL: 106 → 63
Apolipoprotein B: 93 → 75
Triglycerides: 67 → 53
VLDL: 13 → 12
HDL: 56 → 68
Total Cholesterol: 206 → 143
For me, the changes have been very positive overall.
I should mention I also use a systemic .05 estradiol patch that also lowers Lp(a) and I take a 10mg Pravastatin
I’ve had two shots of Leqvio, with a third one scheduled in a couple of weeks. So far, I haven’t had any side effects.
I’ve seen people say that Leqvio doesn’t lower Lp(a), but I think part of the confusion comes from expectations. If someone starts with very high Lp(a), then even a 30% drop might not feel significant to them—yet it’s still a real improvement.
Here are my own results, comparing before Leqvio vs. after Leqvio:
Lp(a): 115.2 → 63 (41% decrease)
LDL: 106 → 63
Apolipoprotein B: 93 → 75
Triglycerides: 67 → 53
VLDL: 13 → 12
HDL: 56 → 68
Total Cholesterol: 206 → 143
For me, the changes have been very positive overall.
I should mention I also use a systemic .05 estradiol patch that also lowers Lp(a) and I take a 10mg Pravastatin
I am jealous of KISU numbers! However, I went to an amazing cardiologist and I achieved a better perspective on the whole thing. I’ve been on LEQVIO for almost 2 years now with no improvement and numbers going in the wrong direction on the LPa. However, all and I mean all of my other lipid numbers have gone in the right direction. What can we learn from that? We have to know if the person in question has the CAD coronary artery disease. I do I inherited that so the inability to bring down my LP little a is going to be influenced by that fact. The cardiologist indicated that I should not be bothered by the score of 88. Of course I’m panicked because they tell you that you should not have a score of over 33. But he said that I don’t even need to worry about bringing it down because a small amount of lipid protects your body against free radicals and cancer. My father in fact had heart disease and brought his all of his lipid numbers down dramatically, however it did not stop his arteries from filling with plaque. He was on statins. I could not take the statins because of the side effect reaction.. I go for every test and image I can ask for and the doctors have a picture of my heart and arteries. That is really the crucial thing here. It doesn’t matter what your numbers are if your coronary arteries and your carotid arteries are in good shape. The lipid numbers Mostly show what’s running through your bloodstream not what’s laid down in your arteries. So anybody who is concerned should get imaging tests and see what their arteries actually look like before they panic. I like the LEQVIO injections because they always clear my nasal passages! The attending nurse has never heard that before, but they do every time. There is zero side effects and its gluten and lactose free so I’m on board.
@jlharsh I just had my first Leqvio injection today, and I’m hopeful I will not have the side effects I had with Repatha and Praluent (injection site rash that got worse each time). But my question for you is about your experience with lipid apheresis. My LP(a) is through the roof, and I have a consultation scheduled regarding apheresis. What can you tell me about it? Thanks very much.
LEQVIO story
I would like to know if others had the same experience that I did.
I began with the LEQVIO shots on April 2024. I experienced much of the same side effects that most people describe in the blogs that I have read. The side effects were supposed to last 5 to 7 days. They lasted a few weeks for me but I tried to tough it out because it was working on lowering my cholesterol.
I did the first shot, after the second shot the side effects were a bit worse but I hung in there. The third shot was the worse….but about four weeks after the third shot I discovered that I was having a very low heart rate, as low as 38.
My Fitbit keeps a permanent daily log and we were able to scroll back and find that these episodes began about 6 weeks after the first shot. It was maybe 2 days out of week approximately. After the second shot the frequency increased and by the third shot, which is when we discovered the problem, it is nearly every day.
I have never had any heart related issues until I began with the shots. We are able to scroll back on the Fitbit data months, even years with no issues.
I have been to the cardiologist and fitted with a monitor for two weeks. The problem did show up on the results. I’ve had an ECHO, which showed the heart is strong but I am experiencing an issue called Bigeminy and Trigeminy.
I stopped the shots, tried to discuss the matter with the Dr. office that arranged the shots but they refused to talk about it and proceeded to tell me as that is not a side affect of the shot and it was a coincidence on the timing of the shots and me coming down with the issue, and since I stopped the shots they refused to look at the printed data because “I am no longer their patient”.
I didn’t accuse, I merely thought the timing was worthy of reporting.
She didn’t.
She also, after telling me this wasn’t a side affect, in the same breath told me the shots are only three years old and all the data isn’t in yet.
I suppose it could have been a coincidence but the timing sure doesn’t look that way to me.
At any rate, has anyone else had this experience with the shots?
@kenjen43 I have Afib, and am on a beta blocker to lessen the episodes of rapid HR but the episodes have been few (i.e. 1-2 x/yr) and irregular HB instances have also been few. Until now. I had my first inclisiran injection on 10/10. About 1 week later I started having instances where the HR wasn't fast but I was very aware HB was irregular. 5 weeks out from injections, I'm still having irregular HB some evenings but not long-lasting instances.
I have not come across the blogs you mentioned. Can you direct me to them? I have also not seen anything about inclisiran aggravating Afib or arrhythmia. But I'm starting to think my symptoms are related. Thoughts?
It’s been a while now. I would just have to google to find them again.
I stopped taking the shots after the third one. I am mostly back to normal.
I experience 2-3 days of low rates maybe about every six weeks but even those are lessening in frequency.
I would not recommend these shots at at.
@llgrnd Thanks for the update. Doing OK. Some irregular heartbeat 7-10 days after shot for several evenings. I have Afib but it rarely acts up (like 1-2x/yr) and take a beta blocker to minimize episodes so it's hard to know cause of recent issues. They seem to have lessened. But the timing and frequency are suspicious. Next injection is January and will have first LDL/HDL test 3+ weeks after that. Time will tell.
@llgrnd Thanks for the update. Doing OK. Some irregular heartbeat 7-10 days after shot for several evenings. I have Afib but it rarely acts up (like 1-2x/yr) and take a beta blocker to minimize episodes so it's hard to know cause of recent issues. They seem to have lessened. But the timing and frequency are suspicious. Next injection is January and will have first LDL/HDL test 3+ weeks after that. Time will tell.
@justlucky I wish you the best. FYI, I had occasional Afib as well, only at night. It seems that sleep apnea was contributing to the Afib, or even the sole cause. I never thought I was a candidate for sleep apnea because I'm petite and in good shape, but sure enough!! Long story, but I now take 100mg of flecainide (an antiarrhythmic) before bed and sleep on my side. No more sleep apnea, and no more Afib!
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I’ve had two shots of Leqvio, with a third one scheduled in a couple of weeks. So far, I haven’t had any side effects.
I’ve seen people say that Leqvio doesn’t lower Lp(a), but I think part of the confusion comes from expectations. If someone starts with very high Lp(a), then even a 30% drop might not feel significant to them—yet it’s still a real improvement.
Here are my own results, comparing before Leqvio vs. after Leqvio:
Lp(a): 115.2 → 63 (41% decrease)
LDL: 106 → 63
Apolipoprotein B: 93 → 75
Triglycerides: 67 → 53
VLDL: 13 → 12
HDL: 56 → 68
Total Cholesterol: 206 → 143
For me, the changes have been very positive overall.
I should mention I also use a systemic .05 estradiol patch that also lowers Lp(a) and I take a 10mg Pravastatin
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1 Reaction@kisu Thank you so much for posting your excellent results! You gave me some hope for my LP(a). I wish you continued success!!
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2 ReactionsI am jealous of KISU numbers! However, I went to an amazing cardiologist and I achieved a better perspective on the whole thing. I’ve been on LEQVIO for almost 2 years now with no improvement and numbers going in the wrong direction on the LPa. However, all and I mean all of my other lipid numbers have gone in the right direction. What can we learn from that? We have to know if the person in question has the CAD coronary artery disease. I do I inherited that so the inability to bring down my LP little a is going to be influenced by that fact. The cardiologist indicated that I should not be bothered by the score of 88. Of course I’m panicked because they tell you that you should not have a score of over 33. But he said that I don’t even need to worry about bringing it down because a small amount of lipid protects your body against free radicals and cancer. My father in fact had heart disease and brought his all of his lipid numbers down dramatically, however it did not stop his arteries from filling with plaque. He was on statins. I could not take the statins because of the side effect reaction.. I go for every test and image I can ask for and the doctors have a picture of my heart and arteries. That is really the crucial thing here. It doesn’t matter what your numbers are if your coronary arteries and your carotid arteries are in good shape. The lipid numbers Mostly show what’s running through your bloodstream not what’s laid down in your arteries. So anybody who is concerned should get imaging tests and see what their arteries actually look like before they panic. I like the LEQVIO injections because they always clear my nasal passages! The attending nurse has never heard that before, but they do every time. There is zero side effects and its gluten and lactose free so I’m on board.
@llgrnd I'm a month behind you. First injection on 10/10. I'll be interested in your progress. 🤞
@kenjen43 I have Afib, and am on a beta blocker to lessen the episodes of rapid HR but the episodes have been few (i.e. 1-2 x/yr) and irregular HB instances have also been few. Until now. I had my first inclisiran injection on 10/10. About 1 week later I started having instances where the HR wasn't fast but I was very aware HB was irregular. 5 weeks out from injections, I'm still having irregular HB some evenings but not long-lasting instances.
I have not come across the blogs you mentioned. Can you direct me to them? I have also not seen anything about inclisiran aggravating Afib or arrhythmia. But I'm starting to think my symptoms are related. Thoughts?
It’s been a while now. I would just have to google to find them again.
I stopped taking the shots after the third one. I am mostly back to normal.
I experience 2-3 days of low rates maybe about every six weeks but even those are lessening in frequency.
I would not recommend these shots at at.
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1 Reaction@justlucky bad cholesterol is under 50
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1 Reaction@justlucky So far so good! Absolutely no side effects at all. 2nd injection coming up in about 3 weeks. I hope you do well too!
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1 Reaction@llgrnd Thanks for the update. Doing OK. Some irregular heartbeat 7-10 days after shot for several evenings. I have Afib but it rarely acts up (like 1-2x/yr) and take a beta blocker to minimize episodes so it's hard to know cause of recent issues. They seem to have lessened. But the timing and frequency are suspicious. Next injection is January and will have first LDL/HDL test 3+ weeks after that. Time will tell.
@justlucky I wish you the best. FYI, I had occasional Afib as well, only at night. It seems that sleep apnea was contributing to the Afib, or even the sole cause. I never thought I was a candidate for sleep apnea because I'm petite and in good shape, but sure enough!! Long story, but I now take 100mg of flecainide (an antiarrhythmic) before bed and sleep on my side. No more sleep apnea, and no more Afib!
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Like -
Helpful -
Hug
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