1. < Osteoporosis & Bone Health
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Forteo Vs Prolia?

Posted by lorkay @lorkay, Nov 11 6:43am

I am considering starting meds for my severe osteoporosis but am weighing the benefits vs the actual increase in bone density. I’ve had two heel fractures first fractures since being diagnosed in 2009
In your experience how long should it take to make a difference to prevent further fractures? Thanks

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

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rjd | @rjd | Nov 16 9:27am
In reply to @osteopatient2026 "@normahorn Any scientific safe way to discontinue Prolia? “Doctors may need to consider discontinuing Prolia” I’ve..." + (show)
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@normahorn
Any scientific safe way to discontinue Prolia?
“Doctors may need to consider discontinuing Prolia”
I’ve read anecdotal stories of reclast being used injected two times instead of the usual one time. Seems there is a lot of tinkering going on…

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@osteopatient2026

You might check out the thread Support for those Quitting Prolia. Contains cites to studies and personal experiences.

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rjd | @rjd | Nov 16 9:28am
In reply to @normahorn "One might want to review what is contained on drugs.com re the effect on immunity. www.drugs.com/medical-answers/prolia-weaken-immune-system-3553497/..." + (show)
Profile picture for njhornung @normahorn

One might want to review what is contained on drugs.com re the effect on immunity. http://www.drugs.com/medical-answers/prolia-weaken-immune-system-3553497/

"Does Prolia weaken your immune system?
Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 9, 2024.

Official Answer by Drugs.com
Yes, Prolia (denosumab) does appear to weaken your immune system. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including serious infections of the skin, abdominal, urinary tract, and ear. There is also a higher chance of developing endocarditis (an infection of the heart’s inner lining, usually involving the heart valves) in those who take Prolia, and those with advanced kidney disease have an increased risk of severe, life-threatening, low calcium levels (hypocalcemia) developing, particularly if they have a metabolic condition called chronic kidney disease-mineral bone disorder (CKD-MBD). For some side effects, people administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk.

Doctors may need to consider discontinuing Prolia in people who develop serious infections or other severe side effects."

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@normahorn

Helpful, as always. Thank you.

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osteopatient2026 | @osteopatient2026 | Nov 16 10:18am
In reply to @gravity3 "@osteopatient2026 Are you looking for links to research on this ? I'm not sure what you..." + (show)
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@osteopatient2026

Are you looking for links to research on this ? I'm not sure what you mean by "tinkering".

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@gravity3
Lol …experimenting

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osteopatient2026 | @osteopatient2026 | Nov 16 10:20am
In reply to @normahorn "@osteopatient2026 I agree that there does not seem to be an established protocol to get off..." + (show)
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@osteopatient2026

I agree that there does not seem to be an established protocol to get off Prolia. My goal, with my depressed immunity, is to never start it.

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@normahorn
What do you think you would use in place of prolia to keep gains from anabolic like forteo or tymlos

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njhornung | @normahorn | Nov 16 12:47pm
In reply to @osteopatient2026 "@normahorn What do you think you would use in place of prolia to keep gains from..." + (show)
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@normahorn
What do you think you would use in place of prolia to keep gains from anabolic like forteo or tymlos

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@osteopatient2026

I am hoping for a low dose (1 mg) ReClast.

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osteopatient2026 | @osteopatient2026 | Nov 16 1:31pm
In reply to @normahorn "@osteopatient2026 I am hoping for a low dose (1 mg) ReClast." + (show)
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@osteopatient2026

I am hoping for a low dose (1 mg) ReClast.

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@normahorn
That’s kind of what my doctor offered as an option too.

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