I am 71 so higher risk. so far so good on Hydra started in May. Random things happen and then go away. Burning on my shins, mouth burning the most is some days I am really tired. Usually comes on suddenly but a nap and all good. I take 500 mg daily and my plates were 297 at last check will have a check on the 19th . Feel tired more and beginning to feel the cold. Which is not usually me . Have not had any sickness at all to pill at night and was having nightmares so switched to morning . I do have other issues in the bathroom but I take Miralax and that works. Good Luck