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Smoldering Myeloma: Coping with the emotional toll and acceptance
Blood Cancers & Disorders | Last Active: Nov 19, 2025 | Replies (18)Comment receiving replies
@msh466
So I have SMM IGA lambda. Low m proteins, low ratio, normal chemistries, no bone lesions. Just the 1q21.3 abnormality and 20% plasma cells in bone marrow. Where it gets fuzzy is all the criteria needed to establish what is what. Mayo uses this, my doctor uses the old standard. 1q21.3 is a high indicator that this will progress, while Mayo doesn’t. This wait and see is difficult. My reasoning is if it went from MGUS to SMM. What’s stopping it to go to the next level?
Replies to "@msh466 So I have SMM IGA lambda. Low m proteins, low ratio, normal chemistries, no bone..."
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@msh466
I understand the frustration from not understanding the criteria. I just got my 10-31-25 follow up pelvic MRI results from 9-15-25. 8-15-25 showed on 13 mm focal enhancement and 10-31-25 showed 3 focal enhancements: 1- 5 x 8 mm, 2 -5 x 6 mm and 3- 4 x 4 mm. MyIgG lambda smm was high risk with 20-30 % plasma cells and 2.2 g/dl m spike and flc less than 0.1.
I have my next round of blood work December 2 and then next followup December 17.
Hoping that I am still watching and waiting even though i want to squash it while I am strong enough! I hope you are still in safe territory and that when the time comes you are prepared to put it in remission!