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Keytruda side effects

Kidney Cancer | Last Active: Nov 27 3:35pm | Replies (23)

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Profile picture for annie0180 @annie0180

I had a right nephrectomy in June 2025…DX: clear cell renal carcinoma. I started on Keytruda in July and get infusions every three weeks until next July. I had to stop taking Diclofenac, which I was taking for arthritis and told not take any anti-inflammatories due to possible bleeding. I have had a lot of bone and muscle pain and hurt with mobility. This has made sleeping difficult because I wake up to change positions.
My oncologist tells me to take Tylenol which does nothing. I never thought it would make me so irritable at times. Okay. That’s enough “boo-hooing” for one day. Suggestions???

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Replies to "I had a right nephrectomy in June 2025…DX: clear cell renal carcinoma. I started on Keytruda..."

@annie0180 there are some good discussions below regarding Claritin and Pepcid!

Welcome, @annie0180. Here are the posts that @susanris was referring to, where @beebe talks about histamines and pain with immunotherapy https://connect.mayoclinic.org/comment/1283215/

I also found this article:
- Boost Your Cancer Immunotherapy: How Common Antihistamines May Improve Treatment Success https://morningsidecenter.emory.edu/promising-therapies/blogs/antihistamine.html

How are you doing with getting enough sleep?