@diannerk In 1992 or 93 I was diagnosed with ET. My platelets were 1.5 million and no side effects from disease. Hydrea was able to get them down to 400k. Another drug came on the market Agrylin, which the doctor thought might be a safer drug. Took it for a few years. Dr was retiring and told him since my blood counts were normal that I was not going to take any more meds. This was before high platelets were classified as cancer! They called it a blood disorder. For at least 20 years, my platelets remained normal until Jun 2025 when I was diagnosed with MF. Hopefully, you’ll do well with this drug since it’s been on the market for years. Wishing you well.