Can ISO PSA test be requested prior to PC diagnosis?

Posted by ezupcic @ezupcic, Nov 10, 2025

Is ISO PSA test something that is usually ordered after PC diagnosis or can it be ordered before to clarify consistently elevated PSA test scores?

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

You might also want to consider the PSE test and attached is a comparison of the two, with sources.

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It only makes sense prior to diagnosis. It’s a test to decide whether to move to MRI and Biopsy if PSA is high. As mentioned, PSE would be an alternative.

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I think the general consensus trends towards the order of: DRE (depreciated)->PSA -> PSE -> MRI -> Biopsy -> Decipher

With all those pieces in hand, you are going to have a solid understanding what, if any at all, your cancer diagnosis is going to be.

That last one is a big one, if not for Decipher I'd be on active surveillance and likely gotten far worse by the time I underwent treatment.

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Profile picture for survivor5280 @survivor5280

I think the general consensus trends towards the order of: DRE (depreciated)->PSA -> PSE -> MRI -> Biopsy -> Decipher

With all those pieces in hand, you are going to have a solid understanding what, if any at all, your cancer diagnosis is going to be.

That last one is a big one, if not for Decipher I'd be on active surveillance and likely gotten far worse by the time I underwent treatment.

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@survivor5280 , just seems like getting a PSE test is really a challenge. Neither my urologist or pcp or any labs near me do it.

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Profile picture for ezupcic @ezupcic

@survivor5280 , just seems like getting a PSE test is really a challenge. Neither my urologist or pcp or any labs near me do it.

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@ezupcic I am sure anxious to read your replies from these good folks, because we've run into that before, too. Where are you located? We are in a town of about of less than 32,000 in NM. We may be having to drive 1hr for certain things. That's why we moved back to TX when my husband was 1st diagnosed in 2021 (that & our fam), but have recently moved back! We recently stopped ADT, & I am hoping for the PSE test every 3mos.

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You can order your own PSA tests through Walk in Labs. They use Quest and others. The pricing is good too.

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Profile picture for bonanzaman @bonanzaman

You can order your own PSA tests through Walk in Labs. They use Quest and others. The pricing is good too.

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@bonanzaman
I don't see the ISO PSA or the PSE test available on their website.

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