I was diagnosed with osteopenia about 15 years ago in my early 50’s. One hip reading was right on the threshold of osteoporosis and considered as such. I was placed on Prolia (a history of stomach ulcers ruled out other meds) and did biannual injections for about a dozen years. I never had any side effects whatsoever and experienced significant improvements in all readings. Two years ago my endocrinologist and I decided that I should transition off Prolia. I have been doing Reclast infusions once or twice a year the last two years and my endocrinologist believes that I will be able to go on a drug holiday shortly. His view is that osteopenia should be treated on a 3-year basis and then re-evaluated. I know that Prolia is controversial but it worked as advertised for me and I have no ill effects at this point.