@khandro100 I was diagnosed in June 2025 with secondary MF after 33 years with ET. Took Hydroxy for a few years and Agrylin for a few years. Decided to stop—-had no side effects on either drug. My BMB in June of this year showed MF. Presently not on any drugs. It hasn’t progressed enough and counts aren’t terrible. I do have headaches, most days stomach aches, and unfortunately now a UTI that requires an antibiotic, which is very hard on the microbiome. I have tinnitus, which may not be related, constipation, fatigue, and feeling “unwell.” Don’t know how to describe it. Haven’t felt well since April. Kinda like the flu w/o fever or aches. Just icky!