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ADT: RO says I need ADT, Urologist says I don't.
Prostate Cancer | Last Active: Nov 9 2:23pm | Replies (19)Comment receiving replies
@melvinw
It’s interesting that the study shows that while there is a higher chance of dementia or Alzheimer’s while on ADT the patients that were off of it also had a pretty high chance of getting it. The differences weren’t that great, At least the additional percentages of those that got dementia because they were on ADT was small compared to those that didn’t take ADT, since they also had a risk of getting Dementia.
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@jeffmarc Yes small numbers in this study. From my readings, studies prior to 2019 didn’t find any association between ADT and cognitive decline (CD). The oldest study I have found, so far, is from 2019 (attached). They suggested that ADT may have an augmenting effect, rather than be a direct cause of CD. The researchers also found a dose dependent relationship. Their concluding statement: “Our results suggest that clinicians need to carefully weigh the long-term risks and benefits of exposure to ADT in patients with a prolonged life expectancy and stratify patients based on dementia risk prior to ADT initiation.”. I took note of that statement because of a history of dementia in my family, but no history of PCa.
jayadevappa et al (2019)_Association between ADT Use and diagnosis of dementia in men with PCa (jayadevappa-et-al-2019_Association-between-ADT-Use-and-diagnosis-of-dementia-in-men-with-PCa.pdf)