My husband is on this combo. Lots of adverse reactions but started immunotherapy and chemo at same time, so hard to say which caused what. Got a weird type of neuropathy or dropped foot, and joint pain, which we think was chemo. Lots of inflammation with immuno. His blood pressure kept going down, very weak and tired, couldn't walk. Ended up with three blood transfusions and three fluid IVs
He developed colitis that didn't get diagnosed for a week because it was more bowl urgency than diarrhea. doctor gave him the opdivo treatment but also started on high dose steroids same day, which is not what seems to be the recommendation. He did great on steroids - appetite/taste buds came back, energy, etc. They were going to discontinue altogether but we were told immunotherapy was only true path to a cure, so we opted to try again. Next treatment (Opdivo and Yervoy) Colitis cage back with a vengeance. Currently back on high dose steroids. He also had IV steroids the first two immuno treatments because he got chemo at same time. Basically only had one or two immunotherapy treatments without steroids so not sure we had much benefit. PET scan showed liver metastases were worse, so they didn't think chemo or immuno did much. We ended up seeing an internal radiation oncologists. He got two of the tumors with ablation. Had planned on doing all for but they had grown too much again. He feels certain that injected radiation beads will take care of other two. Hopefully, that will give us more treatment options for what's left in lung and lymph nodes. The cancer in kind had shrunk, which I think may have been due to just the external radiation. External radiation has caused terrible burning throat but went away after ten days, so we might be able to try that again. The internal radiation oncologist has set up a consult with oncologist and external radiation oncologist for this coming Tuesday. Hopefully they will come up with a good game plan. If I had known then what I know now, I would probably try internal radiation before immunotherapy. To be fair though, according to the oncologist team my husband had had much worse adverse effects than they are used to seeing. Apparently most people get through immunotherapy pretty easily