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I also have worked with neonates..and neonates experience pain and a GOAL in neonatology is to keep the neonate out of pain, and do you know how they do it: with opioids. This is because you cannot use NSAIDs on a neonate. The ONLY use for NSAIDs in neonates is if they are born with a hole in their heart (called a PDA) as the NSAID helps keep the PDA open until the baby can undergo heart surgery safely. HOWEVER, the risk to the neonate is - you guessed it: kidney failure.

It is a balancing act with the human body and it frustrates me physicians don't TOTALLY inform a patient when they prescribe.

IMHO: All people put on ANY drug should know all the facts and pros and cons - over time. Especially older patients and very young patients.

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@slarson14
I too have osteoarthritis. I had both knees replaced starting about 20 years ago. Both were really painful. The doctor asked me which to replace first. I said to do the L one because it was the worst. Once it was done, the R knee quit hurting. Evidently I had been putting extra stress on the R because the L was so painful. Five years later the R knee was replaced. Now some 25 years later, I had a hip replaced one year ago.
My guess is it is the Celebrex that is making you feel tired. I couldn't take it for that very reason. Good luck to you! Hope you find some relief soon.