@szelisk Hi. I had very high calprotectin levels 2.5 years ago and had a colonoscopy that did not reveal anything helpful and now because my calprotectin level is close to 1000, my doctor wants me to have one again. For those of us with severe GI issues, you often have to do the two or three day prep vs. one day and it makes one sick as a dog, so trying to avoid it. What tests did you have done that provided the pancreatic enzyme insufficiency diagnosis. Were you asked to have a colonoscopy because of your high calprotectin level? Really appreciate any advice you are willing and able to share. Best, Gail