I have CMML/MF and have been dealing with itching for ten years. Jakafi works to some extent. Here’s what I do. First, eliminate anything else that might make you itch. I use All free and clear, no fabric softener or anything with scent. I shower with Bioderma Atoderm intensive (white bottle, blue gel) and right after I apply a LOT of jojoba oil (I like Cliganic). I have decided it’s not a histamine thing, it’s a nerve thing. I sleep with a white reusable ice bag. I keep it in a plastic trash can next to the bed so if I itch I can grab it and slap it on without getting up or turning on a light. Whatever you do, don’t scratch. It gets infinitely worse. You can fool the nerves by gently rubbing with your fingertips, also. There are scientific studies that have found that. Mine seems to flare whenever I change clothes. I tried a higher dose of Jakafi but that caused a lot of skin cancer. So I use ice—cheap and it works. Good luck.