@mrsruby Let me add my welcome to Mayo Clinic Connect. I have had 4 BMB, all without sedation. So much depends on the practitioner's experience when the do the procedure, is what I found out. My previous oncologist did my first one, and it was uncomfortable. The last 3 have been by my current hematologist oncologist, and I barely felt anything. I was able to drive my 2 hours back home right away, after each one!

You may experience some localized discomfort. They will use a numbing agent topically [usually lidocaine]. You will probably feel pressure as they use a tool to access the bone marrow. What my guy does is have his nurse right there with me, to talk and distract me, keep my focus off the procedure. We have a good time, laughing about all kinds of things, and she will also rub my hands or arms to distract my physical response. They have a real good system down for doing that!

Please let me know if I can help in any way?
Ginger