@lisanell I’ve been taking HU for 10 years (1000 to 1500mg daily) and it definitely caused redness around the ankles as well as ankle ulcers if my dosage went over 1500mg. Even under 1500mg I had to be very careful about scraping my ankles. These ankle wounds would take a while to heal and would require careful attention. Trust me these symptoms are HU related. I’ve been off HU for 8 weeks and my ankles are no longer red and an ankle ulcers I got cleared up quickly.