Anyone on Gemcitabine with Abraxane? How long? Effective?

@etto Good luck with the CT next week. Please let us know how it goes?

@joealp1
Thank you for your response. Fatigue and flu like symptoms have been my husbands main side effects but fever seems to follow on the 3rd or 4th day after treatment.

@gsterle
Thank you for your response.
He too has lost most of his hair and has fatigue and joint pain

@martyp01
How high did your temp go?

To Helena: For me, an 85 year old 90 pound woman (now), it's working great. My CA marker went from 1100 to 143 and I no longer have abdominal pain. No hair, including eyebrows; some fatigue but that is it. I think I have a reduced dosage (which I asked for) and the infusions are every other week. I was unable to tolerate folfirinox almost 3 years ago and quit; had a Whipple in May 2023; came back to chemo when I was diagnosed with peritoneal carcinomatosis about 5 months ago. I hope you have success with this chemo--don't hesitate to work with your oncologist for a treatment that works for you. I am just grateful for the additional--relatively pain-free--years. Courage, Carrie

Hi,
Gem Abraxane worked for me.
6 months. Then targeted radiation. Stable. 3 top oncologists have nothing to give me at the moment. Hope Kras inhibitors and vaccines will come to the forefront sooner than later.

@shscott My temp got up to 102.

Hi! I was on gem/abraxane for four 1/2 months, every other week. Never had a fever, slight fatigue. I did need the white blood cell boosting shot(s) before every infusion (started with second infusion). And somewhere along the way, I became anemic so I had one blood transfusion and a few iron infusions to deal with anemia. I got pretty weak/dizzy and hemoglobin was very low. I found it "easier" than Folfirinox from 2022. I did do the Paxman Scalp cooling so my hair on my head thinned a bit but never completely fell out. On this chemo, most lose all their hair. No steroids were needed, and not a lot of extra meds to handle side effects. I did lose weight on it.

@tomrennie
Thanks for the kind ask. First CT after starting gemsidabine/abraxane
showed slight reduction in the only met we know of so far (2.5 cm on right ascending colon) and CA19-9 down 300pt, though still very high. So we'll see. Amazing that some here have been on this regime for several years!

My dad's been diagnosed in aug 2025 and we started with Nalirifox. After 4 chemos he started feeling more nauseous and weak. The doctor said as compared to other he has taken it pretty well and that as positive that the PET CT would reflect the same. However it was opposite. His ca19 when diagnosed was 22k which is not 50k. His ggt is 600 above. The doctor has advised for second line of treatment Gemcitabine and abraxane but only when GGT comes down to range of 200-300. We do not want to go for this. From the NGS report we found that there is capza2met found which is the main driver of his cancer. And the other genes are less reactive to chemo drugs. We are thinking that we skip the second like of treatment and start with Crizotinib which is the MET inhibitor tried and tested for MET driver cancer in lungs cancer. Has anyone tried or know someone who can share their experience or thoughts on this ? It would be if great help.