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Pruritus with no visible rash?

Skin Health | Last Active: 22 hours ago | Replies (26)

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My primary diagnosed this as pruritus and prescribed Triamcinolone Acetonide Ointment about 3 years ago. In 2023, I was diagnosed with small-cell lung cancer and started chemotherapy/immunotherapy and the symptoms increased. I continue to use the Triamcinolone, but the itching continues, but not as much. I've even applied a mixture of apple cider vinegar (half and half) with water, and it soothes the itching for the moment, but it is not a cure. I'm beginning to believe it's internal and not a bacteria. I try to be mindful of my diet, cutting down on sugar and eating more plant-based organic foods. I've been to a dermatologist, and they recommended continuing the Triamcinolone, but I'm continuing to experience the itching under my arms and sometimes in my pubic area, especially when I sweat. Any suggestions.

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Replies to "My primary diagnosed this as pruritus and prescribed Triamcinolone Acetonide Ointment about 3 years ago. In..."

@panache22
Sounds so familiar…have you noticed what triggers it to start? Mine is triggered by a change in temperature, even a slight change…I also have severe itch after showering, which is called Aquagenic Pruritus…but the itch is different. About 7 years ago, someone on a Facebook group for AP, discovered that when she took her workout supplements she didn’t itch…she isolated it to Beta Alanine…which is a otc amino acid supplement. I take 750 mg when the itch starts and it kills the itch…lasts for four hours…I take 1500 mg 30 mins before showering. For some strange reason, showering is far less itchy in the evening…
I believe it is some form of neuropathy. I had a full dermatology work up with no success.
I buy the NOW brand of beta alanine from Amazon in 750 capsules. The suggested dose for preworkout is much higher, 2000 mg and can cause a weird tingling on the skin. It is now recognized as a official treatment for Aquagenic Pruritus. I’ve never figured out a name for the change in temperature itch, but beta alanine works for it too…

Here are some links to Medical based websites on the subject of Aquagenic Pruritus that site Beta Alanine as a treatment, so if your dermatologist or any other doctor has looked into it, they would find the information.
I have belonged to a FB Groups for Aquagenic Pruritus for 8+ years and based on members posts, I would estimate that 99% of dermatologist have no clue.
I have been taking this for 7 years, usually 2 to 3 times per day. I have not had any issues with Beta Alanine. It is a amino acid found in our bodies...maybe I have a deficiency and that is why it works?? Who Knows...I'm just glad it works.
https://www.researchgate.net/publication/375122684_Aquagenic_Pruritus_A_web-based_survey_study_exploring_itch_characteristics_therapeutic_options_and_patient_perspectives
https://pubmed.ncbi.nlm.nih.gov/33170524/
https://my.clevelandclinic.org/health/diseases/22516-aquagenic-pruritus
https://dermnetnz.org/topics/aquagenic-pruritus