I was on Humira for 14 years. It worked great. Then I got a bad lung infection. They said my immune system was too depressed. So I came off Humira. I went for 5 years without any biologic. However by the 4 th year the RA was back in full force. So I recently started on Simponi infusions. Within 2 weeks it started helping. I hope this one lasts and I do not get sick. Great thing about Simponi is I can afford it. Infusions are a medical procedure not a drug that has to be purchased on a drug plan. So it is affordable. I am on normal medicare.