Does anyone have info on new treatments against EGFR exon 19 mutation?

Thank you 🙏🏻 this is very helpful.

Hi all,
I'm currently on Tagrisso for exon 19 with mets to bones, ribs, spine, pelvis and thankfully it's working its magic.
I'm wondering if there are any pioneering trials or research going on to find Tagrisso v2 or basically anything to give me hope medium term?
Any hope gratefully accepted!!

@yorkie67 I’m so glad to hear Tagrisso is helping. When you say “working,” do you mean the spots are holding steady or even shrinking? Either way—that’s a win, and I’ll celebrate with you!

A few thoughts that might help: for many of us, Tagrisso is our medium-term hope. Cancer cells tend to grow quickly and dodge normal cell death (apoptosis). Tagrisso doesn’t “hunt down” every cancer cell; it blocks the signaling that turns healthy cells into cancer cells, slowing or stopping spread. That pause can give your body time to do what it’s designed to do—and that’s one reason people with EGFR exon 19 or 21 mutations can live well for many years on targeted therapy.

To your question about “what’s next”: we’re not wishing for “Tagrisso v2” so much as looking toward treatments that can directly eliminate remaining cancer. Sometimes tumors learn to bypass Tagrisso, and the path forward depends on what changes they develop. That’s why updated biomarker testing is so important—it tells your team what to target. Chemo and immunotherapy can help in certain scenarios, but it’s very individual. Amivantamab (sometimes paired with lazertinib) is one option in the toolkit because it targets EGFR and the MET pathway; whether it fits depends on your specific results. And just to avoid confusion—when you write “mets,” if you mean metastases, there may also be local options depending on where they are.

If you want to dig deeper, the International Association for the Study of Lung Cancer (iaslc.org) is a great home base. Their Lung Cancer 360 resources—webinars, posters, conference updates—are excellent, and the annual Targeted Therapies of Lung Cancer meeting shares the latest on drugs like Tagrisso. MD Anderson in Houston also has widely respected EGFR expertise if you ever want another set of eyes.

I know I can be wordy, but I hope this offers clarity and hope. You’re not alone in this. Keep the questions coming, and we're cheering for you every step!

@flusshund thank you so much for taking the time to reply , wordy is fine !
The Osi shrunk the main tumour significantly to 17mm at the first 3 month scan and totally wiped out the small brain mets. Everything else has been stable for the last 9 months so I've thankfully been living a normal life for the last 12 months since diagnosis.
I don't want it to end but I know Osi doesn't last forever sadly.Hence the question , is there something new coming down the line? I have mets in my spine , pelvis and ribs but apparently it seems that local radiotherapy to those areas can help.
I haven't looked into 2nd line treatment as I want to spend my time in the "here and now" and not worrying too much about the "what ifs", however I was wondering if there's any hope around the corner ?
I can do wordy too 🙂

@yorkie67, Welcome to Mayo Connect. We have a village of helpful people here with a variety of lung cancer types represented. I'm so very thankful for the willingness of Mathew K to add to our EGRF discussions! Lung cancer has evolved to include many types of cancer, and the treatments are rapidly changing. I can relate to wanting to know 'what's next', just knowing that there is something else is reassuring. I was diagnosed with ALK positive lung cancer over five years ago. I'm fortunate to be holding steady on my first-line targeted therapy. Over the years there have been advances, and my plan for a second line has even changed twice because of new research, drugs and combinations of drugs. We're always looking toward the next thing. That hope is all we have somedays, but keep doing what you love, and spending time with those that love you. The future of lung cancer has never been more hopeful.

@yorkie67 this presentation from Dr Janne at Dana Farber is about a year old, but he discusses resistance after Tagrisso. (He's one of the co-discoverers of the EGFR mutations in NSCLC.)

@mamajite
Thanks for this x

@lls8000
Thanks that's great to hear !

I still have NOT consulted with an oncologist. Next week will be my first apt. I pray my issue can be resolved with right doctor and right treatment plus right medications.
Pray for me.
rlf66

Thanks to everyone for the info. My mom is on Tagrisso and it’s gotten rid of metastases in her brain, shrunk the cells in liver and lung. One side effect she’s experiencing is lots of peeling and dry skin. Anyone have any good remedies / support for that?