@bmekdec, it helped me almost right away. I was suffering pretty bad with chest pain, asthma—like and sinus inflammation, never heartburn, and I felt relief within days. I combined it with H2 blockers since PPIs made everything worse. Good luck! It was hard to get at first, especially in the quantity I needed for long-term. I stayed on it for about 6-7 months full-time then on/off for another few months. I have a half case in the closet that still unexpired I wish I could give it to you!