@candrgonzalez a friend of mine just has acid reflux and Fosamax really inflamed her esophagus. I have acid reflux and a generally horrible g.i. tract and opted for Prolia. Prolia has caused side effects (mentioned on this site before. Recap: made my IBS-C worse, made my arthritis worse, made my high cholesterol worse). Decision re taking 4th injection or taking Reclast instead, or not treating the osteoporosis and risking rebound fractures from going off Prolia without a backup drug. Have until July to decide. Prolia has not caused acid reflux issues for me. All drugs cause side effects. You dont know until you give it a go. Its the old risk vs benefit.