After the Prolia disaster I took the RECLAST infusion, only 1/2 dose since it is in your system for 6 months and longer. I have digestive issues (lactose intolerance, fructose malabsorption, etc.) and the doctor said it wouldn't affect my stomach like the bisphosphonates pills. Wrong! I had HORRIBLE side effects, not just gastrointestinal issues but dozens of others. This is the worst medicine I've ever had and I think it should be removed from the market. Either that or they should learn how to tell if someone shouldn't take it ahead of time, since there is no antidote. You can find a list of the side effects on the Mayo Clinic site - look under drugs, and type in zoledronic acid. The list is 3 or more pages long! Besides trashing my G.I. tract (I had had it all under control before this), it screwed up a bunch of other body systems. I couldn't even plug a cord into an outlet without getting out of breath. The first time I couldn't get my breath back for 2 days so finally went to the ER. They found nothing so I know it was that (plus it happened multiple times after that). I bought a can of aviators oxygen from the Harriet Carter catalog and have used that multiple times to get my breath back. My bone density only increased 3% for all I had to go through. I got the infusion in April 2019 and am still not back to normal. Have you tried Forteo? That is a drug you inject into yourself daily. That has the advantage of bypassing the GI tract plus you can quit anytime if you need to. Anyway, never again for the 6 month drugs. My next plan is to try an oral bisphosphonate you take weekly or monthly. Good luck with whatever decision you make!