I am 65, female, and about to receive my fourth Prolia injection. I am afraid of drugs and have a track record of reacting to meds. I know there are many papers in medical journals outlining negative effects of Prolia and other osteoporosis drugs. However unlike the doctors who specialize in this area who have four years of medical school plus another 4-6 years of residency and some who continue on doing research in this area, how can we ever really know what the doctors know? My own endocrinologist heads up the osteoporosis department in a major hospital in a large city. She has led the research in studying astronauts and weightlessness in space and bone loss. These doctors see the whole picture, have read many more papers than we ever will, have seen so many patients over many years. I do feel that my endocrinologist has my best interests at heart. And as someone who is scared of drugs, I made a decision to trust my doctor who seems quite dedicated to her patients.
Exercise, calcium, vit d was never going to "cure" my osteoporosis. My bone density has increased on Prolia and I worry a little less about fracturing. Science is always evolving and five years from now there may be something new to try.