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Is PSA rise inevitable after hormone therapy?
Prostate Cancer | Last Active: Oct 22 11:18am | Replies (57)Comment receiving replies
Prostate c discovered summer of 2021. Gleason high 7 — decided to have prostatectomy. Residual c on bladder neck. PSA increased rapidly post surgery - decided to have Decipher test - results .97… Hormone therapy and prostate bed radiation began September of 2022. Non-detectable until late summer 2024. Was enrolled in Pluvitco study late 2024 - control Arm - but had frequent checks and eventually went through metastasis into bone — discovered over 30 Mets in late May this year. Now undergoing triplet therapy (chemo, hormone and Nubeqa)… just wondering what my outlook is, given all parameters. I’ve now had 5 (of 6) chemo treatments. Been told the hormone and Nubeqa will be administered indefinitely…Receiving care at Siteman Cancer Center (St. Louis) — I LOVE my “team” and am confident they are managing my case well. Just always wonder - what’s left?
Replies to "Prostate c discovered summer of 2021. Gleason high 7 — decided to have prostatectomy. Residual c..."
@bjrhinos1
In 2010 I had surgery because they said I had a 3+4 Gleason. After surgery, it turned out it was a 4+3. 3 1/2 years later, my PSA started rising so they did salvage radiation. That lasted 2 1/2 years before my PSA started rising again, and I went on Lupron.
I have a genetic problem, BRCA2, Which is why it keeps coming back. Have you had genetic testing? That could be why your cancer keeps coming back and if it’s the same genetic issue, as I have, there is a drug specifically for it.
After four reoccurrences, I am now on Orgovyx And Nubeqa. It is kept my cancer undetectable for the last 23 months. I did have to have a metastasis in my spine, zapped a couple of years ago, The drugs seem to keep everything under control.
You can Get genetic testing to find out if it could be a factor. Does anybody else in your family have cancer? You can get it here for free, If you live in the USA,, takes 2 to 3 weeks to get the results and a genetic counselor will call you. They will send you a kit that you return in the mail. Don’t say you want your doctor involved or they will hold off sending the kit until they contact your doctor.
Prostatecancerpromise.org
While Pluvicto Works well for some people. It only works real well for 1/3 of people OK for 1/3 of people and not at all for 1/3 of people. Some genetic problems, cause it to not work well. It sounds like it didn’t work too well for you, But the amount of time it actually is effective is not that long for many people.
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@bjrhinos1 Since you're polymetastatic, you're in a different situation than mine, but there are other members here who've been keeping their cancer under control for quite a while using ADT and one of the -lutamides (like Nubeqa), with the occasional chemo or spot radiation to manage flare-ups.
I *can* say from personal experience that long-term ADT and ARSI became much less of a big deal for me over time. At first, they really knocked me out. Now, after 4 years continually on ADT and Apalutamide (Erleada), they've become just background noise in a happy, reasonably-active life.
p.s. For ADT, I strongly recommend Orgovyx (daily pills) over Firmagon or Lupron (periodic injections) if you can manage it. They're all equally effective and have similar chronic side-effects, but the pills avoid the flare-up of acute side-effects (e.g. swelling and several days of flu-like symptoms) that I got after each Firmagon injection into my abdomen during my first 2 1/2 years, before Orgovyx became available in Canada.