Hello to all. I was diagnosed with stage 1 grade 1 er positive breast cancer in 2105. In addition to radiation I was prescribed anastrolzole and then fosamax to offset the bone density risk from the anastrozle as I had osteoporosis in hip. After 6 months on fosamax with some digestive issues my doctor switched me to prolia injections and I agreed based on the understanding that the prolia would leave my system permanently when I ceased it. I fully intended to cease it within several years. After 3 years on prolia and and anastozole I had such Terrible joint pain . In back and hip I could hardly walk. After stopping the anastozole I saw some improvement in joint pain . But still was in pain. That is when I realized the prolia must be part of the problem. At that point I decided to cease all these drugs but discovered the research on prolia discontinuation spinal fractures and consulted an endocrinologist. I am now moving from Prolia back to fosamax for 2 years to avoid the risk of spinal fractures due to discontinuation..... assuming I can tolerate the side effects of fosamax. . I am doing this only because I am fearful of the multiple spinal fracture risk which is permanently disabling as best I can tell. Anyone considering prolia must read the research on the multiple spinal fractures upon discontinuation. . Just google prolia discontinuation and you will find many research articles and case summaries. If you take prolia there is no clear exit strategy. I am now very cautious about any of these drugs. Undoubtedly they are very useful for patients who have severe risk of bone breaks at outset. However I am 69 have never broken a bone other then high school basketball finger break and my parents lived to 91 mother and 95 father still living neither of whom had ever broken a bone. I do not believe my fracture risk justifies these kinds of drugs nor the risks of the adverse effects. Yet now I am at risk due to the drug......... please get well informed before you consider this drug and be SURE it is right for you.