Mayo's Article on Treating Prostate Cancer 17 October 2025

@westernflyer

Thanks for the additional details.

Found the original research paper and ran it through perplexity.ai to find its connection to sulforaphane.

This research paper indicates that sPOM121 boosts the expression of β-catenin, leading to PCa tumor progression and immune evasion.

Inhibiting the sPOM121/β-catenin axis, in preclinical prostate cancer models, halted tumor aggressiveness and strengthened antitumor immunity.

Apparently, Sulforaphane also acts as a Wnt/β-catenin pathway inhibitor, thus the connection you suggest.

However, this particular research paper did not directly investigate sulforaphane, much less suggest a dosage.

Upon further investigation, I found an unrelated Human Clinical Trial investigating the impact of sulfuraphane in BCR. A short AI summary is outlined below:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4390425/
Phase II Trial in Biochemical Recurrence (NCT01228084)
• Formulation: Sulforaphane-rich broccoli sprout extract capsules (each 50 µmol sulforaphane).
• Dose: 200 µmol daily, taken orally as four 50 µmol capsules before breakfast.
• Duration: 20 weeks.
• Outcome: Well tolerated (no grade 3/4 toxicity); about 35% showed modest PSA declines or slowing of PSA doubling time.

A 200 µmol sulforaphane daily dosage (used in this study), is about 3.5-4 ounces of raw, freshly sprouted broccoli (one loosely packed cup) per day.

I like the taste of broccoli sprouts and I started eating one cup per day about 3 months after I was diagnosed in October 2023.

My PSA level dropped from 7.8 (May 2023 - prebiopsy) to 5.8 by February 2024.

Of course, I implemented many diet and exercise changes in the first 3 months after diagnosis, so there is likely to be multiple explanations.

My latest PSA level was 5.76, unchanged over 16 months.

As there appears to be some solid science behind sulfuraphane and now a potential mechanism, I’ll have to add some credit to my broccoli sprouts and HIT to explain my slowing PSA velocity…

Thanks again for this reference!

All the best!

@handera Ed, this study contained TWENTY men - not thousands. Also, it failed to bring down PSA levels by at least 50% in all cases but a few.
The big takeaway was that it was well tolerated and did no harm…not exactly a ringing endorsement, which I think you would agree with.
I think your massive increase in exercise and all the favorable components of it - especially dropping excess weight and improving insulin resistance has a lot more to do with your success.
That said, the study is old and it would be great if more work was done on the connection to cruciferous vegetables and PCa. In the meantime, sprouts are delicious, packed with nutrients and low in calories so enjoy them! Best,
Phil

My latest batch of broccoli sprouts attached…almost ready to harvest.

Stainless steel trays, broccoli seeds (I add a few radish seeds for a zestier taste) and rinse twice a day….harvest in 5 days….start a new batch immediately for continuous supply.

Been growing and enjoying my own sprouts for two years. The most economical, freshest way to enjoy sprouts!

Thanks for posting!

Reference: Dr. Rhonda Patrick. Yes, her background with Google search is focused, in part on food groups which can have an influence on overall health to include the prostate. I copies this article from 2006 from UCLA (my alma mater) . It is for general information-take from it what you can!
************************************************July 1, 2006***************************************************
Drinking an eight ounce glass of pomegranate juice daily increased by nearly four times the period during which PSA levels in men treated for prostate cancer remained stable, a three-year UCLA study has found.

The study involved 50 men who had undergone surgery or radiation but quickly experienced increases in prostate-specific antigen or PSA, a biomarker that indicates the presence of cancer. UCLA researchers measured "doubling time," how long it takes for PSA levels to double, a signal that the cancer is progressing, said Dr. Allan Pantuck, an associate professor of urology, a Jonsson Cancer Center researcher and lead author of the study.

Doubling time is crucial in prostate cancer, Pantuck said, because patients who have short doubling times are more likely to die from their cancer. The average doubling time is about 15 months. In the UCLA study, Pantuck and his team observed increases in doubling times from 15 months to 54 months, an almost four-fold increase.

"That's a big increase. I was surprised when I saw such an improvement in PSA numbers," Pantuck said. "In older men 65 to 70 who have been treated for prostate cancer, we can give them pomegranate juice and it may be possible for them to outlive their risk of dying from their cancer. We're hoping we may be able to prevent or delay the need for other therapies usually used in this population such as hormone treatment or chemotherapy, both of which bring with them harmful side effects."

The study appears in the July 1 issue of Clinical Cancer Research, the peer-reviewed journal of the American Association of Cancer Research.

"This is not a cure, but we may be able to change the way prostate cancer grows," Pantuck said. "We don't know yet the specific factors behind this response - that's our next step in this research. We want to find out what cell signaling pathways might be affected, what is happening to keep PSA levels stable."

Pomegranate juice is known to have anti-inflammatory effects and high levels of anti-oxidants, which are believed to protect the body from free-radical damage. It also contains poly-phenols, natural antioxidant compounds found in green tea, as well as isoflavones commonly found in soy, and ellagic acid, which is believed to play a role in cancer cell death.

"There are many substances in pomegranate juice that may be prompting this response," Pantuck said. "We don't know if it's one magic bullet or the combination of everything we know is in this juice. My guess is that it's probably a combination of elements, rather than a single component."

The levels of PSA in men immediately following treatement should be undetectable, Pantuck said. If PSA can be detected, it's an indication of an aggressive cancer that is likely to progress. The men in Pantuck's study all had detectable PSA following treatment. Of the 50 men enrolled, more than 80 percent experienced improvement in doubling times.

Conventional treatment for men with recurrent prostate cancer includes hormonal therapy, a chemical castration which removes testosterone from the system. Men treated with hormonal therapy can experience hot flashes, osteoporosis, fatigue, depression, muscle wasting, loss of libido and erectile dysfunction. If drinking pomegranate juice can delay or prevent the need for hormonal therapy, patients would experience a better quality of life for a longer time, Pantuck said.

The patients in Pantuck's study experienced no side effects and none of the participants had cancers that metastasized during the study.

Pantuck, along with UCLA colleagues including Dr. Arie Belldegrun, professor and chief of urologic oncology, and Dr. David Heber, professor and director of the Center for Human Nutrition, first began research on pomegranate juice in prostate cancer about six years ago, conducting preclinical research in cell cultures and in animals. Those studies showed pomegranate juice slowed the growth of prostate cancer, Pantuck said.

The data was impressive enough to test pomegranate juice in clinical trials, Pantuck said. To confirm their findings, a larger Phase III study, headed up by UCLA, will be conducted at ten centers across the county. UCLA is the only Southern California center involved in the study. For more information on the Phase III trial, call (310) 825-5538.

Pantuck said he has men on the study more than three years out who are not being treated for prostate cancer other than drinking pomegranate juice and their PSA levels continue to be suppressed.

"The juice seems to be working," he said.

Nothing follows.........................

Reference: Dr. Rhonda Patrick. Yes, her background with Google search is focused, in part on food groups which can have an influence on overall health to include the prostate. I copies this article from 2006 from UCLA (my alma mater) . It is for general information-take from it what you can!
************************************************July 1, 2006***************************************************
Drinking an eight ounce glass of pomegranate juice daily increased by nearly four times the period during which PSA levels in men treated for prostate cancer remained stable, a three-year UCLA study has found.

The study involved 50 men who had undergone surgery or radiation but quickly experienced increases in prostate-specific antigen or PSA, a biomarker that indicates the presence of cancer. UCLA researchers measured "doubling time," how long it takes for PSA levels to double, a signal that the cancer is progressing, said Dr. Allan Pantuck, an associate professor of urology, a Jonsson Cancer Center researcher and lead author of the study.

Doubling time is crucial in prostate cancer, Pantuck said, because patients who have short doubling times are more likely to die from their cancer. The average doubling time is about 15 months. In the UCLA study, Pantuck and his team observed increases in doubling times from 15 months to 54 months, an almost four-fold increase.

"That's a big increase. I was surprised when I saw such an improvement in PSA numbers," Pantuck said. "In older men 65 to 70 who have been treated for prostate cancer, we can give them pomegranate juice and it may be possible for them to outlive their risk of dying from their cancer. We're hoping we may be able to prevent or delay the need for other therapies usually used in this population such as hormone treatment or chemotherapy, both of which bring with them harmful side effects."

The study appears in the July 1 issue of Clinical Cancer Research, the peer-reviewed journal of the American Association of Cancer Research.

"This is not a cure, but we may be able to change the way prostate cancer grows," Pantuck said. "We don't know yet the specific factors behind this response - that's our next step in this research. We want to find out what cell signaling pathways might be affected, what is happening to keep PSA levels stable."

Pomegranate juice is known to have anti-inflammatory effects and high levels of anti-oxidants, which are believed to protect the body from free-radical damage. It also contains poly-phenols, natural antioxidant compounds found in green tea, as well as isoflavones commonly found in soy, and ellagic acid, which is believed to play a role in cancer cell death.

"There are many substances in pomegranate juice that may be prompting this response," Pantuck said. "We don't know if it's one magic bullet or the combination of everything we know is in this juice. My guess is that it's probably a combination of elements, rather than a single component."

The levels of PSA in men immediately following treatement should be undetectable, Pantuck said. If PSA can be detected, it's an indication of an aggressive cancer that is likely to progress. The men in Pantuck's study all had detectable PSA following treatment. Of the 50 men enrolled, more than 80 percent experienced improvement in doubling times.

Conventional treatment for men with recurrent prostate cancer includes hormonal therapy, a chemical castration which removes testosterone from the system. Men treated with hormonal therapy can experience hot flashes, osteoporosis, fatigue, depression, muscle wasting, loss of libido and erectile dysfunction. If drinking pomegranate juice can delay or prevent the need for hormonal therapy, patients would experience a better quality of life for a longer time, Pantuck said.

The patients in Pantuck's study experienced no side effects and none of the participants had cancers that metastasized during the study.

Pantuck, along with UCLA colleagues including Dr. Arie Belldegrun, professor and chief of urologic oncology, and Dr. David Heber, professor and director of the Center for Human Nutrition, first began research on pomegranate juice in prostate cancer about six years ago, conducting preclinical research in cell cultures and in animals. Those studies showed pomegranate juice slowed the growth of prostate cancer, Pantuck said.

The data was impressive enough to test pomegranate juice in clinical trials, Pantuck said. To confirm their findings, a larger Phase III study, headed up by UCLA, will be conducted at ten centers across the county. UCLA is the only Southern California center involved in the study. For more information on the Phase III trial, call (310) 825-5538.

Pantuck said he has men on the study more than three years out who are not being treated for prostate cancer other than drinking pomegranate juice and their PSA levels continue to be suppressed.

"The juice seems to be working," he said.

Nothing follows.........................

@westernflyer

Thanks for this post! I incorporated Pomegranate juice into my diet early into my AS protocol, along with ceremonial grade Jade Matcha tea (breakfast).

It turns out there is currently a randomized double-blinded Phase II clinical trial underway that is evaluating the bioavailability, safety, effectiveness and validate the mechanism by which a standardized formulation of whole Green Tea Catechin, (Sunphenon® 90D) containing 405 mgs affects men diagnosed with localized PCa in AS.
https://blog-ecog-acrin.org/trial-spotlight-nagi-kumar-on-the-ea8184-study-for-men-with-low-grade-prostate-cancer-on-active-surveillance/
I like to go with “whole foods” rather than supplements, but incorporated this into my daily diet back in November 2023….there was enough of a “hint” even back then…

I still think my HIIT training is primary…but when you’ve committed to AS you don’t pass up promising, low risk, dietary changes….that taste good!