Why are cancer markers 15-3 and 19-9 rising while CA-125 isn’t?

@naturegirl5 No, my oncologist didn't explain why these markers were ordered or why they continue to order them. I had asked about them and why they were elevated and he didn't answer me (not that I can recall anyway). That was my first oncologist, the one who treated me with carbo/paclit. Then I switched oncologists as I went in for a clinical trial testing Enhertu. I has asked the nurse the significance of the markers and she said they don't really go by the markers. I've been receiving CT scans every 6 weeks on this trial, and the tumors are shrinking, and one has disappeared, for all intents and purposes. Yet 19-9 and 15-3 still show slight elevation. So, I'm still in the dark.

@cookercooker it is appalling that your questions were not answered. In a clinical trial these markers may be used in the data analysis to see if they are useful for monitoring cases like yours. In real clinical use, these markers *may* indicate other cancers in different organ systems, but they would only be raising a flag that would require follow-up, they are not diagnostic in and of themselves. For example, people with high ca 19-9 sometimes have pancreatic cancer or bile duct cancer, but they can also have an inflammation of the pancreas or even gall bladder issues. Do you have a new oncologist besides the clinical trial team, or do they have an oncologist who will answer your questions about the possible need for follow-up?