Has anyone taken Atelvia Delayed Release and what is your opinion?

Posted by dalejandre @dalejandre, Oct 17 6:58pm

I have not taken any osteoporosis drugs but the doctors say I should. My research indicated bisphosphonates being best. I also read that Atelvia Delayed Release did not have many bad effects.
Please comment if you have any knowledge about this medication.
Thank you kindly.
Kelda

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All I know about atelvia is that it is a biphoshonate that was designed to bypass the stomach and is instead absorbed in the small intestine. Theoretically this sounds like a great plus. Most oral biophosponates can cause bad stomach and esophageal issues- this is why you must remain staipnding for an hour after you take them. I guess the question is does the reality stand up to the hype? I will look up some articles on Google scholar and see what they say

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Sorry, the studies I found just reititerate above. I did find that altevia is much better absorbed than other biphosphonantes (most have about a 1% absorption. There was some concern about the high amounts of ECTA in the formulation, and the study ended with a comment that the ideal oral biphosphonate has yet to be developed. Also noted that most biphosphonates are generic. Altevia is not. So with most insurance companies will require a prior authorization. Wish I could have been more help

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Profile picture for laura1970 @laura1970

Sorry, the studies I found just reititerate above. I did find that altevia is much better absorbed than other biphosphonantes (most have about a 1% absorption. There was some concern about the high amounts of ECTA in the formulation, and the study ended with a comment that the ideal oral biphosphonate has yet to be developed. Also noted that most biphosphonates are generic. Altevia is not. So with most insurance companies will require a prior authorization. Wish I could have been more help

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@laura1970 I see there is generic: Risendronate.
Another brand name is Actonel.

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Profile picture for laura1970 @laura1970

Sorry, the studies I found just reititerate above. I did find that altevia is much better absorbed than other biphosphonantes (most have about a 1% absorption. There was some concern about the high amounts of ECTA in the formulation, and the study ended with a comment that the ideal oral biphosphonate has yet to be developed. Also noted that most biphosphonates are generic. Altevia is not. So with most insurance companies will require a prior authorization. Wish I could have been more help

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@laura1970
Thank you for your reply. I do not know what is ECTA but will look it up.

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The problem with bisphosponates is that while it prevents bone loss, it does not allow for bone renewal. This can make the bones more brittle as young new bone is more flexible than older bone.
But I am not a doctor. Just adding to your research.

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Profile picture for brendammc @brendammc

@laura1970 I see there is generic: Risendronate.
Another brand name is Actonel.

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@brendammc I looked it up and you are correct. I was reading original studies that were probably written before it went generic. Thanks for the correction!

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Profile picture for laura1970 @laura1970

All I know about atelvia is that it is a biphoshonate that was designed to bypass the stomach and is instead absorbed in the small intestine. Theoretically this sounds like a great plus. Most oral biophosponates can cause bad stomach and esophageal issues- this is why you must remain staipnding for an hour after you take them. I guess the question is does the reality stand up to the hype? I will look up some articles on Google scholar and see what they say

Jump to this post

@laura1970 & Kelda: 15 years ago I started having a lot of abdominal distress. I won't get into the details but I lost 27 pounds in two years and wasn't trying to. I see an osteopath (that is NOT a chiropractor, by the way) regularly for my on-going back issues. He documented my weight loss. I was referred to a gastroenterologist and after having both a colonoscopy and an endoscopy I was diagnosed with celiac disease. (That explained a lot of problems throughout my life but won't go into that on this post.) I was referred to Stanford. The gastroenterologist there, who specialized in celiac disease, told me the tips of my small intestine villi were damaged and would never really rejuvenate. The tip is what digests lactose so I am now lactose intolerant as well as wheat, gluten, barley, rye intolerant. (The latter being from celiac disease.) Thank you for posting that ATELVIA bypasses the stomach and is absorbed through the small intestine. This would be a medicine I could never take as my small intestine is already compromised because of celiac disease. If bisphosphonates are known to cause stomach and esophageal irritation I would also worry about small intestine irritation/damage. The small intestine's primary function is to absorb the nutrients from digested food.

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Profile picture for Maryann @mkoch

@laura1970 & Kelda: 15 years ago I started having a lot of abdominal distress. I won't get into the details but I lost 27 pounds in two years and wasn't trying to. I see an osteopath (that is NOT a chiropractor, by the way) regularly for my on-going back issues. He documented my weight loss. I was referred to a gastroenterologist and after having both a colonoscopy and an endoscopy I was diagnosed with celiac disease. (That explained a lot of problems throughout my life but won't go into that on this post.) I was referred to Stanford. The gastroenterologist there, who specialized in celiac disease, told me the tips of my small intestine villi were damaged and would never really rejuvenate. The tip is what digests lactose so I am now lactose intolerant as well as wheat, gluten, barley, rye intolerant. (The latter being from celiac disease.) Thank you for posting that ATELVIA bypasses the stomach and is absorbed through the small intestine. This would be a medicine I could never take as my small intestine is already compromised because of celiac disease. If bisphosphonates are known to cause stomach and esophageal irritation I would also worry about small intestine irritation/damage. The small intestine's primary function is to absorb the nutrients from digested food.

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@mkoch
I wonder if instead of damaging the esophagus it will damage the intestines. Does anyone have any knowledge about Atelvia? Please let me know. I am (was) seriously consider taking it but scared to get intestinal problems.
Thank you for your report.

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Profile picture for dalejandre @dalejandre

@mkoch
I wonder if instead of damaging the esophagus it will damage the intestines. Does anyone have any knowledge about Atelvia? Please let me know. I am (was) seriously consider taking it but scared to get intestinal problems.
Thank you for your report.

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@dalejandre
Could anyone let me know if they have been successful with Fosamax. That mainly means, no esophageal problems.
The new medications, like ATELVIA, which I am considering, have not proven themselves but Fosamax seems to have had a long successful existence. Since Atelvia affects the small intestine , because that is where it is absorbed I am afraid it may damage it just as some bisphosphonates affect the esophagus.
Please help. I have to decide which med to take. Thank you kindly.

Please someone respond. I have to dec

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I am on my second round of Fosamax and have been fortunate not to have experienced any negative side effects. I took it for 5 years after fracturing my wrist and subsequently being diagnosed with osteoporosis, took a 3 year drug holiday and then re-started Fosamax due to worsening T scores. The only side effects I experienced during the first couple of months was some bone pain the first few days after taking the medicine. I do have concerns about continuing this second round of Fosamax and therefore am getting another opinion from an Interventional Medicine clinic next month. This online support group has been extremely helpful and resourceful so my list of questions for the new provider is quite long!

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