I agree that no one knows the long-term effects of these drugs. I stopped Prolia after three injections due to a number of side effects, and regret not doing enough research before starting. My internist had been telling me for ten years that I HAD to do something and that the choices were Prolia and Forteo, so I rather blindly agreed to Prolia. I was not told about the potential for rebound fractures when stopping, hence, the need to stay on it forever or switch to another drug. I had extreme fatigue, a persistent cough with mucous, episodes of vertigo, acid reflux, joint pain, itchy skin, and hair loss, with most setting in after the third injection. I saw specialists to rule out other causes for those conditions before deciding to stop Prolia. All of those conditions have improved since stopping. If I were fracturing, I would be more willing to endure side effects, but I am not willing to endure a dramatic loss of quality of life otherwise. And I am now taking my chances that I will be one who suffers rebound fracturing, because I didn't go on another drug. I feel that I am worse off than when I started. I am also one of those who was prescribed Fosamax in the mid-90s when it first came out as a preventative measure, and I didn't even have osteoporosis. It was prescribed to me year after year for nearly 15 years. I just recently learned through my extensive research on these drugs that Fosamax taken for that long can permanently alter the structure of the bones, and is now prescribed for only a very short period of time. All of that said, I know that there are people who take Prolia with no side effects, and that it can be a godsend to someone who is fracturing.