If you google either Dr.Jonathan Adachi or "how long can you stay on Prolia", all questions about Prolia are answered. Adachi is one of the leading osteoporosis experts here in Canada. There have been large studies done. You can stay on Prolia for ten years. Yes, going off Prolia abruptly may cause compression fractures. I have never learned how to provide the link to articles (will find out, its embarassing). This is a great article. There is about 12 years of data on Prolia.