I have been taking Hydroxyurea for over 1 year. Started taking 1000mg daily and experienced horrifying night sweats and mouth sores. My hematologist decreased dosage to 500 mg daily and the side effects were much easier to deal with. I now take 500 mg every other day and life is good. There's no side effects and platelets are around 500. I'm 72 years old so in a higher risk category, but I think Hydroxyurea is great. Good luck to you.