I am 64 on prolia for almost one year. Have a terrible gut before the Prolia: celiac disease, IBS-c, acid reflux. My constipation and loss of appetite problem has become severe in the last two months. Now dependent on laxatives which are creating new g.i. problems. I do have a suspicion that the Prolia is a contributing factor. In the process of getting to the bottom of this. Next injection supposed to be in May. Are you still on Prolia?