I have had a Prolia shot once a year for 3 years. I have had infections within the 6 months after each shot requiring antibiotic treatment each time. Prolia seems to affect my immune system so I am not going to take any more injections. I think the Infections may kill me before the fractures do but I am carefully watching my diet, doing yoga, cardio and weight training!! We shall see how this works!! I am also taking Algaecal because I can’t tolerate other calcium supplements. I am working up to 2 tablets daily and so far so good.