Two months before I turned 50 I tripped and fell and broke my left wrist. Becuse I had read an article in NPR, I inisisted on a Bone Density Scan. I live in Switzerland and my doctor here was not in agreement but I insisted. I was diagnosed with Osteoporosis and took Bonviva injections for two years. It got worse and I switched to Prolia. I just had my DEXA scan last week after two years on Prolia and there is improvement in my bone density... still Osteoporosis though. I am 54 now and in trying to get to the root cause have discovered Normocalcemic Hyperparathyroidism. In September I had to have my thyroid removed and one parathyroid. Now my parathyroid hormone is through the roof again am scheduled for a scan at the beginning of January hoping to find the troublesome parathyroid and have it removed. Hyperparathyroidism contributes to Osteoporosis. This was a long winded reply to say... so far, Prolia has worked for me and I have no side effects that I know of. At my age and the level of my Osteoporosis, I am trusting my specialist. It does worry me though that I can never go off of this sort of medication.