I am scheduled for my 4th Prolia injection on December 26 and am in the throes of making the decision to go forward. At my insistence, my specialist did testing (a urine test) to determine whether or not Prolia is working. He called me yesterday with the results which show that I am not losing bone and, in his opinion, it is working. He readily agreed with me that there simply are no good options for treatment. He mentioned a drug in use in Europe that has not been approved by the FDA for use here. Starting at some point in the 90's, I was on Fosamax for years. At the time, doctors were apparently prescribing it as a preventative measure, and I have read that use of this drug has contributed to negative alterations to our bones. My sister was hospitalized for two weeks in serious condition as a result of her esophagus being entirely ulcerated. Her doctors said it was caused by Fosamax, and that was the point where I stopped it myself. The negatives from Fosamax weren't determined until there was data available from years of use. I fear the same will come to be true with Prolia. While I have experienced some side effects such as fatigue, acid reflux, chronic cough, joint pain, vertigo, and hair thinning, at age 75 there is no way to prove that all are due to Prolia. As a part of making a decision to go forward, I've seen my internist for other causes of the fatigue (he could find none), an ENT to rule out other reasons for the cough and vertigo (he also found none). and another specialist for ongoing pain in knee joints (xrays showed no reason). I am also working with a physical therapist to develop an exercise routine that I can safely do for overall strengthening. I have fairly severe osteoarthritis in my hands which has proven to be problematic when doing things like lifting weights, so I wanted guidance from a professional who would take that into consideration. Because of the experience you and others have experienced with rebound fractures, I am feeling trapped with no option but to continue. It's difficult to subject myself because at month six since my last injection, I am actually feeling good.