@tikigod18 Hello: Thank you for sharing this terrifying experience. I am glad that your friend's wife is getting better now day by day and glad for her that she only ever had the one injection. I have been on Prolia for two + years and due a 5th shot in March. Because of constant neck pain and pain in both shoulders as well as increased pain in my back area where I have a scoliosis I have decided not to go forward with Prolia. I did not know until recently that it had become a drug that was now being recommended to stay on forever. I was offered it when it first came out and was told at that time you could only stay on it for two years. It is only recently that I have seen more and more coming out that there can be a severe rebound effect if you stop using it. I am especially interested in what someone's experience is after being on it for two years or more and then stopping. Best wishes to you and to your friends, Ann.