Thank you to all who shared their side effects. I have familial hypercholesterolemia. I inherited it from my father's side of the family. I was raised in an environment where it was inconvenient for you to be sick. You were supposed to tough it out and not bother anyone. Statins did not work so I was Rxed Repatha. My first try was for 3 months in 2023 but I had diarrhea interfered with my job and didn't remit until I stopped taking it. My second try came a year later until I gave up in August of this year. I had diarrhea again but it stopped and turned into constipation so that was progress I guess. I wish I had read your stories sooner. I felt like I was the one failing to adjust when other problems occurred. I reported that the muscle fatigue and joint pain was keeping me from walking. I felt like I had the flu with night sweats immediately after each dose. I had sinus infections, UTI, and increased asthma symptoms. I was gaining weight. I tried spacing out the doses. My insurance dropped payment at one point and I noticed that I felt better without Repatha in my system but I started back up. Then I had severe back and shoulder pain so I stopped completely. Now I can see that symptoms I attributed to aging or other things were also probably Repatha. I have been off of it for 2 and a half months. Somethings have improved but the fatigue, muscle weakness, joint and back pain and increased asthma symptoms have not. Today I am going to see another specialist. It makes me wonder how many other people are out their trying to be "good patients" and are not speaking up.