@drsuefowler Would you mind sharing where you heard that Progesterone may increase osteoblasts. This is the first I have heard of this and would love to learn more. My understanding is that women who still have a uterus must take Progesterone when taking Estrodot. I am currently taking 100 mg of micronized progesterone nightly combined with small dose Estrodot patch, also prescribed by my functional physician and have had a small increase in BMD over a 10 month period. My physician said that the BHRT would stop the bone loss and may provide some small gains, but if so I would need to remain on it to maintain the gains. She didn't explain the reason for possible small gains.