Biden undergoing radiation along with hormone therapy

They told me I had up to a year to do the radiation to the prostate after my bone-metastatic prostate cancer diagnosis, but I elected to do it sooner. Post-op radiation to the metastasis was the top priority.

As long as your PCa remains castrate-resistant and undetectable on the ultrasensitive PSA test (< 0.01), it's almost certain that the cancer isn't progressing, so you have a bit of breathing room. It's the systemic therapy (ADT + ARSI) that has to start as soon as possible.

I hope the best for former President Biden, as I do all of my fellow prostate cancer patients.

Amen!!

Yes, my understanding is that they wait at least three months with radiation after starting ADT+ARSI to weaken the cancer and make it more susceptible to the radiation treatment.

In my case started radiation 6 weeks after Orgovyx (and Extandi added two weeks later, so 4 weeks for it).

Mine was not aggressive, just unfavorable intermediate. My SBRT started after two weeks on Orgovyx. Perhaps two weeks was enough to weaken the cancer cells and make them more susceptible to treatment?

@vircet To be fair, I've never heard about the "weakening the cancer cells before radiation" part (that doesn't mean it's not true; just that I've never stumbled across it).

@northoftheborder I "stumbled across it" just today. I might have read before that ADT before surgery or radiation can prevent the cancer cells from growing, but this "weakening the cancer cells" @topf is even better.

@topf
For me:
Orgovyx for 30 days prior to SBRT and orgovyx for 90 days post. MSK trained radiologist (David Byun) at Tallwood Men's Health Hartford under the direction of my urologist, surgeon Joseph Wagner.

I am: PSA 4.1, Gleason 7 (3+4) with cribriform in 2 tumors - gleason 6 in 2 tumors.

My RO explained ADT shrinks the field and makes radiation more effective.

A recent UCLA video revealed Stereotactic Body Radiation SBRT can now be used effectively to target (and presumably destroy) up to 12 metastatic PC lesions wherever they are in the body. Look up Dr Michael Steinberg video lecture on Dr Scholz PCRI website for details

I will bet this is the plan being used for Joe Biden

@vircet Same exact thing here. Eligard then radiation 2-3 weeks after.