@anavleek Need a break from the HU and Besremi will work on my potential to develop a resistance to HU after so many years. I also am having the beginning of PV, at least my blood work shows some changes that made my hematologist recommend it. Starting to have some heart problems, as it relates to ET ? maybe, numbers are showing some heart failure. Just trying to hang on as long as possible. I am 67 now and was diagnosed with ETJAK2 when I was 32.