@mmwagner46 Serotonin Syndrome is when taking too much medication that helps the brain produce serotonin, produces too much. It can be dangerous. Sometimes if someone is on an anti-depressant (an SSRI or an SNRI) and takes another medication that causes the brain to produce serotonin, it can be dangerous. Google "Serotonin Syndrome." Trazadone is an old anti-depressant that I have used for sleep for years now. I also take Cymbalta, 30 mg. I have taken 100 mg of Trazadone with the Cymbalta (which I take in the morning) and have not had an issue, however, as others have said, talk to your doctor about dosage.