Tymlos vs. Evenity

Posted by eliz4142 @eliz4142, Mar 8, 2024

Hi all. I experienced a compression fracture at L1 about 4 weeks ago and this is how I learned I have osteoporosis. I'm "only" 57 and, after having a lot of blood work done, there is no explanation for my bone loss. I was adopted, so I don't have a lot of information about my genetics. Seems it's just an unusual (though not unheard of) situation. Since I've experienced a fracture already, my doctor has advised me that I need an anabolic agent. I'm trying to decide between 24 months of daily Tymlos or 12 monthly injections of Evenity. The doc assures me both are really effective. Evenity seems to have some serious (though unlikely) side effects, but definitely seems like a more palatable regimen. Any thoughts or experiences that might help me decide would be appreciated! Thank you!!

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Profile picture for bktexas @bktexas

Thx for your kind reply! Simply said, we just do not know. Have you had any side effects from the Tymlos? My dr had said I might feel dizzy, so might have to sit or lay down for awhile.
If I may ask, was it your dr recommendation to start HRT along with the Tymlos? My dr didn't mention HRT at all.
By all means, wish you the very best with your treatment. I'd love to be kept in the loop!

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I do not have side effects with Tymlos. But b4 I inject each morning I drink a full glass of water with a pinch of mineral salt. Also I always move afterwards doing physical chores, or going for a walk. I do not think I wd feel good if I were to lay down. As for HRT-I chose that on my own to help combat any negative effects from Tymlos such as fatigue, wt. gain, etc. I also do weights and want to increase my chance of muscle building. When I look at my health history, ie: cancer and bone loss, these both occurred post estrogen loss so I decided to add that back in to help maintain and generally feel better. I take estradiol patch, progesterone pill at nite and testosterone cream. I will post any updates along my journey. I am hoping for any better alternative over bisphosphonates by the time I end Tymlos.

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I am 55 and was diagnosed with severe Osteo at 51 after breaking a rib. I’ve broken 11 bones in the last 22 years. I’m
Pretty active year round with outdoor sports and a gym junkie. I was very shocked to get this news. I’ve been doing natural path care for 4 years. I’ve been able to get my bone turnover to a normal after it was extremely high, but I continue to lose bone density in my hip now at -2.5 and -2.7, lumbar got a tiny bit better now at -3.4. I’ve decided to start a med and am also debating between the two you mentioned. Any advice is welcome. I get another Dexa scan next month and hoping for better numbers. I also started using a vibrating pad for home workouts for a year now. Fingers crossed!

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Profile picture for ceccy @ceccy

I am 55 and was diagnosed with severe Osteo at 51 after breaking a rib. I’ve broken 11 bones in the last 22 years. I’m
Pretty active year round with outdoor sports and a gym junkie. I was very shocked to get this news. I’ve been doing natural path care for 4 years. I’ve been able to get my bone turnover to a normal after it was extremely high, but I continue to lose bone density in my hip now at -2.5 and -2.7, lumbar got a tiny bit better now at -3.4. I’ve decided to start a med and am also debating between the two you mentioned. Any advice is welcome. I get another Dexa scan next month and hoping for better numbers. I also started using a vibrating pad for home workouts for a year now. Fingers crossed!

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@ceccy good luck, thanks for sharing. I’ve had 4 vertebral fractures this in a year. Dr started me on Tymlos 2 months ago. I also have severe stenosis in my neck, affecting my arms. Have had so many dexamethasone injections. Already have fusion in next in ‘05.
The vertebrae above and below are deteriorating . I’m in constant pain. I’m praying the Tymlos works, side effects suck, but I push through. Just has injections in C456 today. Arm feels better. Warm wishes E

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Profile picture for osteoresearch @osteoresearch

I do not have side effects with Tymlos. But b4 I inject each morning I drink a full glass of water with a pinch of mineral salt. Also I always move afterwards doing physical chores, or going for a walk. I do not think I wd feel good if I were to lay down. As for HRT-I chose that on my own to help combat any negative effects from Tymlos such as fatigue, wt. gain, etc. I also do weights and want to increase my chance of muscle building. When I look at my health history, ie: cancer and bone loss, these both occurred post estrogen loss so I decided to add that back in to help maintain and generally feel better. I take estradiol patch, progesterone pill at nite and testosterone cream. I will post any updates along my journey. I am hoping for any better alternative over bisphosphonates by the time I end Tymlos.

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@osteoresearch I’m struggling with the side effects from Tymlos. I couldn’t possibly do anything after the injection. My brain goes into a spin, headache, and nausea.
It comes on within 3-10 minutes post injection. 2 months now. I wake up sometimes with the room spinning and a pounding head. I’m hoping things ease up soon. Warm wishes E

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Profile picture for eileenvan @eileenvan

@osteoresearch I’m struggling with the side effects from Tymlos. I couldn’t possibly do anything after the injection. My brain goes into a spin, headache, and nausea.
It comes on within 3-10 minutes post injection. 2 months now. I wake up sometimes with the room spinning and a pounding head. I’m hoping things ease up soon. Warm wishes E

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@eileenvan I get headaches too post injection. And some back pain as well

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Profile picture for taraneh64 @taraneh64

@eileenvan I get headaches too post injection. And some back pain as well

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@taraneh64 It’s a brain fog that’s really bad. Within 3 - 10 minutes post injection. Lasts about an hour.
I already have back pain. (And neck pain from severe stenosis)
Warm regards
E

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This is so helpful. I am 58 and just diagnosed with severe osteoporosis. I have been looking into Tymlos and Evenity as well. About to start HRT after results of bloodwork come back. It's kind of daunting. It seems like both drugs have good and bad. I was leaning towards Tymlos. I meet with my rheumatologist Monday to see what she recommends. Has anyone had any issues with insurance coverage of these drugs? This disease really throws you for a loop when you are completely healthy and active!! Thanks for any feedback.

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Profile picture for osteoresearch @osteoresearch

I do not have side effects with Tymlos. But b4 I inject each morning I drink a full glass of water with a pinch of mineral salt. Also I always move afterwards doing physical chores, or going for a walk. I do not think I wd feel good if I were to lay down. As for HRT-I chose that on my own to help combat any negative effects from Tymlos such as fatigue, wt. gain, etc. I also do weights and want to increase my chance of muscle building. When I look at my health history, ie: cancer and bone loss, these both occurred post estrogen loss so I decided to add that back in to help maintain and generally feel better. I take estradiol patch, progesterone pill at nite and testosterone cream. I will post any updates along my journey. I am hoping for any better alternative over bisphosphonates by the time I end Tymlos.

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@osteoresearch
I am going to begin hrt but I haven't decided yet if I want to do the testosterone. My doctor recommends the pellets but I'm not sure if I want that. I'm also a little worried about the side effects of testosterone. Have you had any side effects?

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Profile picture for dianat @dianat

@osteoresearch
I am going to begin hrt but I haven't decided yet if I want to do the testosterone. My doctor recommends the pellets but I'm not sure if I want that. I'm also a little worried about the side effects of testosterone. Have you had any side effects?

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@dianat
Hi Dana,
I am loving HRT and no I haven't had any side effects but I would not do pellets, personally. I don't like anything that stays in my system for months. I do the daily cream you apply to your inner thighs. So if you notice any side effects you can adjust accordingly. I have a lot more energy, less brain fog, better libido. The only side effect I've noticed but so minimal I barely feel the need to mention it but I notice a few more hairs around my mouth and chin I have to pluck but again you can adjust your dose if you do not like any of the side effects. It's a small price for me compared to feeling good. Hope this helps.

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