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Methotrexate risks versus inflammation risks

Posted by cptrayes @cptrayes, Sep 17 11:28am

Rheumatology want to put me on methotrexate but I want to make a rational decision about it. I feel well and have none of my RA/vasculitis symptoms, likely due to a raft of supplements I'm taking. But my CRP is 17 when it should be nothing, and is classed as high in the UK
Nobody in rheumatology wants to talk to me about the risks of continuing with a raised CRP versus the risks of both methotrexate itself (mostly kidney and liver) and the risk of lowering my immune system and catching bugs.

Can anyone help? Thanks!

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cptrayes | @cptrayes | Sep 29 11:13am
In reply to @pb50 "@cptrayes i have been diagnosed with RA since 2012. I initially began on Humira auto pen..." + (show)
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@cptrayes i have been diagnosed with RA since 2012. I initially began on Humira auto pen with methotrexate… the belief being there was a synergistic effect of the two drugs being more effective together than either was alone. But the MTX jacked up my liver enzymes. They kept decreasing the Mtx dosage and i developed antibodies to the Humira. So he switched me to Enbrel + MTX. That worked pretty well until the liver enzymes started to rise again. I went initially to injection of MTX rather than oral and that held things at bay - until it didn’t. So in 2020 I changed docs and started on Remicade infusions. No MTX. And still am on that program today.

so hang in and be willing to make changes…

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@pb50 I'm pleased you've found stuff that works for you. I remain in remission, as far as I can tell) with non prescription, (but still powerful), drugs.

I'll be taking my next CRP test in a couple of weeks to see where it's going.

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