@kjoauch Jak2 positive can be diagnosed from a single lab test. It’s very expensive and takes a few weeks for results usually. It’s means you actually have the mutation in your bone marrow and will be something you have for life. If that test is negative, most likely you have some sort of disease elsewhere that is causing your labs to be high. Sometimes they can find that and treat it and you’re done. Other times people have PV and are not JAK2 positive and still live with it. Just like some of us have high platelets, like myself and others do not. If you have high platelets you have to take meds for life to avoid clots, strokes and heart attacks. I’m in this for almost three years now. PV and JAK2 Positive. I’m 59 now and never had health issues or good meds. Good luck!