@eleanorrigby I had a single mastectomy 9 years ago, followed by 7 years of Anastrazole, and lots of Zometa infusions. During the treatment, I had joint pain increase, lots of hair loss, and neuropathy in my toes. It is only recently, in the past 6 months or so, that I am no longer losing lots of hair. I now have osteoporosis, worst in my wrists, and one hip, and lots of joint pain which may or may not have been exacerbated by the medicine. Same for neuropathy; many factors can influence conditions. No weight loss for me.