I take 150 mg monthly. Prior to this I had three annual infusions of Reclast with no side effects and also no improvement in my bone density. I had to switch specialists because the one I was seeing retired and and my new NP switched me to risedronate sodium because she was concerned about Reclast's higher probability of kidney damage. Never took alendronate. I was stubborn and trying to manage my osteopenia with exercise and diet, and had a steady decrease in my bone density.