@sylvieanne While we wait for other members who have been on Avastin to respond I'd like to welcome you to Mayo Clinic Connect and to our Gynecological Cancers Support Group.

It must have have been very good news to your when your recent CT showed no evidence of cancer. I did not have ovarian cancer and so have not had C-125 tests. My understanding from what I have read is that there can be variations in C-125 due to a variety of factors that are not necessarily related to ovarian cancer.

CA-125-Mayo Clinic:

-- https://www.mayoclinic.org/tests-procedures/ca-125-test/about/pac-20393295

What did your doctor says about the C-125 number? And your bone pain?

I receive Avastin currently as maintenance therapy, right after I finished 6 cycles of chemo,
which also included Avastin. I'm scheduled for my 15th infusion and will have had 18.
My experience with it include many side effects, some have subsided, others hang on. Fatigue is one
of them, also bone pain but tolerable. Fatigue and bone pain are more prevalent in the first week after the infusion. I force myself to fight the fatigue and do some physical work instead of staying in bed. It gets better in the 3rd week then it starts all over. Your CT scan shows no evidence of cancer-that is very good news. There could be various reasons why the CA125 went up, but it is still in normal range. Is your oncologist concerned? How often is your CA125 checked? Mine is tested every 3 weeks with the infusion.
I understand that any rising CA125 can cause worries.