← Return to Problems months after colon resection surgery: What Helps?

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@ron7614

I was wondering if anyone has had experience with use of the antidepressants for chronic pain following partial colectomy. I know that they use low doses of the tricycliclics like amitriptyline but given that I tend toward constipation and the TCA's can cause constipation, I have been considering a trial of duloxetine(Cymbalta) an SNRI which might be helpful. Has anyone had experience with this?

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Replies to "I was wondering if anyone has had experience with use of the antidepressants for chronic pain..."

@ron7614, I noticed that you wished to post a URL to a study article with your message. You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe. Clearly the link you wanted to post are not spam, so allow me to post it here.

– The Use of Antidepressants in the Treatment of Irritable Bowel Syndrome and Other Functional GI Disorders https://www.med.unc.edu/ibs/files/2017/10/IBS-and-Antidepressants.pdf

First, you should not develop chronic pain after surgery. If pain persists after six weeks, check with your doctor concerning causation of pain. Antidepressants do not treat pain (at best, they make you a bit numb and distance you emotionally from psychic pain), and it becomes very hard to withdraw from the SSRIs and SNRIs, so better never to start them. The older tricyclic antidepressants in very low doses cause you to be sleepy and thus help with sleep. (Other sleep meds are often addictive, so this is a good choice if pain is making it hard to sleep.) Of course, all medications should be discussed with your doctors. Remember that they are often quick to prescribe and slow to deprescribe.